Reactome | S100A8:S100A9:Ca2+ [extracellular region]

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S100A8:S100A9:Ca2+ [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6798474] S100A8:S100A9 binds Zn2+ - Homo sapiens [Reaction:R-HSA-6798528] S100A8:S100A9 binds Mn2+ - Homo sapiens
created	[InstanceEdit:8944199] Shamovsky, Veronica, 2016-11-03
dbId	8944198
deleted	[Deleted:8944203] Deletion of instance: 6798392
displayName	S100A8:S100A9:Ca2+ [extracellular region]
hasComponent	4 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] 2 × [Complex:R-HSA-5432834] S100A8:S100A9 [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-8944198] S100A8:S100A9:Ca2+ [extracellular region] - Mus musculus [Complex:R-RNO-8944198] S100A8:S100A9:Ca2+ [extracellular region] - Rattus norvegicus [Complex:R-CFA-8944198] S100A8:S100A9:Ca2+ [extracellular region] - Canis familiaris [Complex:R-BTA-8944198] S100A8:S100A9:Ca2+ [extracellular region] - Bos taurus [Complex:R-SSC-8944198] S100A8:S100A9:Ca2+ [extracellular region] - Sus scrofa [Complex:R-XTR-8944198] S100A8:S100A9:Ca2+ [extracellular region] - Xenopus tropicalis
isChimeric	false
literatureReference	[LiteratureReference:6798486] Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis [LiteratureReference:5432754] The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins [LiteratureReference:6798424] Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 are confirmed by electrospray ionization-mass analysis [LiteratureReference:6798433] Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity
maxDepth	3
name	S100A8:S100A9:Ca2+ calprotectin heterotetramer
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8944198

Referrals

(replacementInstances)	[Deleted:8944203] Deletion of instance: 6798392
(hasComponent)	[Complex:R-HSA-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]
(input)	[Reaction:R-HSA-6798528] S100A8:S100A9 binds Mn2+ [Reaction:R-HSA-6798474] S100A8:S100A9 binds Zn2+

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