Reactome | S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]

Schema > Complex > Entries

S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
created	[InstanceEdit:6798553] Shamovsky, Veronica, 2015-09-19
dbId	6798411
displayName	S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]
hasComponent	2 × [SimpleEntity:R-ALL-266099] Mn2+ [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region] [Complex:R-HSA-8944198] S100A8:S100A9:Ca2+ [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Mus musculus [Complex:R-RNO-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Rattus norvegicus [Complex:R-CFA-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Canis familiaris [Complex:R-BTA-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Bos taurus [Complex:R-SSC-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Sus scrofa [Complex:R-XTR-6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - Xenopus tropicalis
isChimeric	false
literatureReference	[LiteratureReference:6798486] Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis [LiteratureReference:5432754] The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins [LiteratureReference:6798544] Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
maxDepth	4
modified	[InstanceEdit:8944201] Shamovsky, Veronica, 2016-11-03
name	S100A8:S100A9:Ca2+:Mn2+:Na+ calprotectin heterotetramer
producedByEvent	[Reaction:R-HSA-6798528] S100A8:S100A9 binds Mn2+ - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6798411
updateTrackers	[UpdateTracker:9895330] Update Tracker - [Complex:6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - v59:[addSpecies, add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9895330] Update Tracker - [Complex:6798411] S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] - v59:[addSpecies, add_removeHasComponent]
(output)	[Reaction:R-HSA-6798528] S100A8:S100A9 binds Mn2+

© 2026 Reactome

Cite Us!