EGR1 binds the PTEN gene promoter

Stable Identifier
R-HSA-8944078
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EGR1 binds the PTEN gene promoter
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In response to UV-induced DNA damage, expresion levels of both EGR1 and PTEN increase. EGR1 binds directly to the EGR1 binding site GCGGCGGCG in the promoter region of PTEN to stimulate PTEN transcription (Virolle et al. 2001).
Literature References
PubMed ID Title Journal Year
11781575 The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

Baron, V, Virolle, T, Mustelin, T, Birle, D, Adamson, ED, de Belle, I, Mercola, D

Nat. Cell Biol. 2001
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Authored
Salmena, L  (2016-08-11)
Carracedo, A  (2016-08-11)
Orlic-Milacic, M  (2015-10-29)
Created
Orlic-Milacic, M  (2016-11-02)
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