Reactome | US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane]

Schema > Complex > Entries

US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] Show undefined attributes

catalystActivities	[CatalystActivity:8943123] ubiquitin protein ligase activity of US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
consumedByEvent	[BlackBoxEvent:R-HSA-8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 - Homo sapiens
created	[InstanceEdit:8943110] May, Bruce, 2016-10-24
crossReference	[DatabaseIdentifier:12020774] Mondo:0850289
dbId	8943093
disease	[Disease:9830824] human cytomegalovirus infection
displayName	US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane]
hasComponent	[Complex:R-HSA-8943101] TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] [Complex:R-HSA-8943114] US11:HLA [endoplasmic reticulum membrane]
inDisease	true
literatureReference	[LiteratureReference:8943130] A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation [LiteratureReference:8943094] TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
maxDepth	5
modified	[InstanceEdit:9840700] May, Bruce, 2023-07-24
name	US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2
producedByEvent	[Reaction:R-HSA-8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP - Homo sapiens
relatedSpecies	[Species:2671791] Human cytomegalovirus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8943093
updateTrackers	[UpdateTracker:9905073] Update Tracker - [Complex:8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] - v84:[updateContainedComponent] [UpdateTracker:9906127] Update Tracker - [Complex:8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] - v86:[addDisease, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9905073] Update Tracker - [Complex:8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] - v84:[updateContainedComponent] [UpdateTracker:9906127] Update Tracker - [Complex:8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] - v86:[addDisease, updateContainedComponent]
(output)	[Reaction:R-HSA-8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
(input)	[BlackBoxEvent:R-HSA-8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
(physicalEntity)	[CatalystActivity:8943123] ubiquitin protein ligase activity of US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane]