Reactome | RUNX3 regulates CDKN1A transcription

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RUNX3 regulates CDKN1A transcription Show undefined attributes

authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
created	[InstanceEdit:8941857] Orlic-Milacic, Marija, 2016-10-06
crossReference	[DatabaseIdentifier:12819607] BioModels Database:BIOMD0000000997 [DatabaseIdentifier:12819609] BioModels Database:BIOMD0000000342 [DatabaseIdentifier:12819611] BioModels Database:BIOMD0000001001 [DatabaseIdentifier:12819613] BioModels Database:BIOMD0000001003 [DatabaseIdentifier:12819615] BioModels Database:BIOMD0000000989 [DatabaseIdentifier:12819617] BioModels Database:BIOMD0000000499 [DatabaseIdentifier:12819619] BioModels Database:BIOMD0000000995 [DatabaseIdentifier:12819621] BioModels Database:BIOMD0000000173 [DatabaseIdentifier:12819623] BioModels Database:BIOMD0000000998 [DatabaseIdentifier:12819625] BioModels Database:BIOMD0000000996 [DatabaseIdentifier:12819627] BioModels Database:BIOMD0000000990 [DatabaseIdentifier:12819629] BioModels Database:BIOMD0000001000 [DatabaseIdentifier:12819631] BioModels Database:BIOMD0000000999 [DatabaseIdentifier:12819635] BioModels Database:BIOMD0000001002 [DatabaseIdentifier:12819637] BioModels Database:BIOMD0000000994
dbId	8941855
displayName	RUNX3 regulates CDKN1A transcription
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8878143] RUNX3 binds SMAD3 and SMAD4 - Homo sapiens [Reaction:R-HSA-8878178] The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8878186] CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 - Homo sapiens [BlackBoxEvent:R-HSA-8878117] RUNX3 binds ZFHX3 - Homo sapiens [BlackBoxEvent:R-HSA-8878130] CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 - Homo sapiens [Reaction:R-HSA-8952128] RUNX3 binds TP53 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8878139] RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD [LiteratureReference:8878107] Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction [LiteratureReference:8952120] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	RUNX3 regulates CDKN1A transcription
orthologousEvent	[Pathway:R-CEL-8941855] RUNX3 regulates CDKN1A transcription - Caenorhabditis elegans [Pathway:R-DME-8941855] RUNX3 regulates CDKN1A transcription - Drosophila melanogaster [Pathway:R-GGA-8941855] RUNX3 regulates CDKN1A transcription - Gallus gallus [Pathway:R-XTR-8941855] RUNX3 regulates CDKN1A transcription - Xenopus tropicalis [Pathway:R-DRE-8941855] RUNX3 regulates CDKN1A transcription - Danio rerio [Pathway:R-SSC-8941855] RUNX3 regulates CDKN1A transcription - Sus scrofa [Pathway:R-BTA-8941855] RUNX3 regulates CDKN1A transcription - Bos taurus [Pathway:R-CFA-8941855] RUNX3 regulates CDKN1A transcription - Canis familiaris [Pathway:R-RNO-8941855] RUNX3 regulates CDKN1A transcription - Rattus norvegicus [Pathway:R-MMU-8941855] RUNX3 regulates CDKN1A transcription - Mus musculus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8941855
summation	[Summation:8941871] RUNX3 contributes to the upregulation of the CDKN1A (p21) ge...

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[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3

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