Reactome | Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange

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Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10426180
displayName	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
eventOf	[Pathway:R-BTA-5654693] FRS-mediated FGFR1 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-BTA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-BTA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-BTA-5654587] Activated FGFR1:p-FRS phosphorylates PPTN11 - Bos taurus
regulatedBy	[Requirement:10426181] Requirement by 'Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8941623
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5654693] FRS-mediated FGFR1 signaling
(inferredTo)	[Reaction:R-HSA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange

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