RNF152 polyubiquitinates RRAGA

Stable Identifier
Reaction [omitted]
Homo sapiens
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When the cellular concentration of amino acids is low, the ubiquitin E3 ligase RNF152 (Zhang et al. 2010) transfers ubiquitin from the E2-ubiquitin conjugate UBE2N:Ubiquitin to RRAGA (RagA GTPase) (Deng et al. 2015). RNF152 polyubiquitinates RRAGA with lysine-63 linked ubiquitin, which recruits GATOR1, an inhibitor of RRAGA. The inhibition of RRAGA, in turn, inhibits mTORC1 thereby regulating activity of mTORC1 in response to amino acids (Deng et al. 2015). RNF152 is located in the lysosomal membrane and can autoubiquitinate (Zhang et al. 2010).

Literature References
PubMed ID Title Journal Year
21203937 RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities

Wu, W, Zheng, J, Tang, H, Wu, Y, Suo, T, Zhang, S, Tang, J

Protein Cell 2010
25936802 The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation

Chen, L, Li, D, Jin, J, Chen, M, Xu, Y, Wang, P, Pan, W, Deng, L, Zhao, L, Liao, L, Wang, X, Wei, J, Chu, H, Li, L, Jiang, C, Liu, M, Ge, X

Mol. Cell 2015
Catalyst Activity

ubiquitin protein ligase activity of RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane]

Orthologous Events
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