Reactome | Synthesis of GABA by GAD2

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Synthesis of GABA by GAD2 Show undefined attributes

authored	[InstanceEdit:888594] Mahajan, SS, 2010-06-29
catalystActivity	[CatalystActivity:888587] glutamate decarboxylase activity of PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
category	transition
compartment	[Compartment:917757] clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [Compartment:917758] clathrin-sculpted gamma-aminobutyric acid transport vesicle
created	[InstanceEdit:888571] Mahajan, SS, 2010-06-29
crossReference	[DatabaseIdentifier:12667465] RHEA:17786
dbId	888577
displayName	Synthesis of GABA by GAD2
edited	[InstanceEdit:918281] Mahajan, SS, 2010-08-03
eventOf	[Pathway:R-HSA-888568] GABA synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:888576] GAD2 on chromosome 10p12 is a candidate gene for human obesity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Synthesis of GABA by GAD2
orthologousEvent	[Reaction:R-CEL-888577] Synthesis of GABA by GAD2 - Caenorhabditis elegans [Reaction:R-DME-888577] Synthesis of GABA by GAD2 - Drosophila melanogaster [Reaction:R-GGA-888577] Synthesis of GABA by GAD2 - Gallus gallus [Reaction:R-XTR-888577] Synthesis of GABA by GAD2 - Xenopus tropicalis [Reaction:R-DRE-888577] Synthesis of GABA by GAD2 - Danio rerio [Reaction:R-SSC-888577] Synthesis of GABA by GAD2 - Sus scrofa [Reaction:R-BTA-888577] Synthesis of GABA by GAD2 - Bos taurus [Reaction:R-CFA-888577] Synthesis of GABA by GAD2 - Canis familiaris [Reaction:R-RNO-888577] Synthesis of GABA by GAD2 - Rattus norvegicus [Reaction:R-MMU-888577] Synthesis of GABA by GAD2 - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-352011] GABA [cytosol]
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-888577
summation	[Summation:888578] GAD65 or GAD2 is concentrated in the nerve terminal region i...
updateTrackers	[UpdateTracker:9777762] Update Tracker - [Reaction:888577] Synthesis of GABA by GAD2 - v69:[removeInput, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9777762] Update Tracker - [Reaction:888577] Synthesis of GABA by GAD2 - v69:[removeInput, removeOutput]
(hasEvent)	[Pathway:R-HSA-888568] GABA synthesis
(precedingEvent)	[Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen