Synthesis of GABA by GAD2

Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GAD65 or GAD2 is concentrated in the nerve terminal region in the neurons and is involved in the synthesis of GABA which is used as a neurotransmitter.

Literature References
PubMed ID Title Journal Year
14691540 GAD2 on chromosome 10p12 is a candidate gene for human obesity

Bekris, L, Neve, B, Dubois, S, Séron, K, Vasseur, F, Corset, L, Dina, C, Chikri, M, Clement, K, Vasseur-Delannoy, V, Lernmark, A, Boutin, P, Cabellon, J, Froguel, P, Charles, MA

PLoS Biol 2003
Catalyst Activity

glutamate decarboxylase activity of PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Orthologous Events
Cross References
Cite Us!