Reactome | Synthesis of GABA by GAD2

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Synthesis of GABA by GAD2 Show undefined attributes

catalystActivity	[CatalystActivity:10857535] glutamate decarboxylase activity of PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
category	transition
compartment	[Compartment:917757] clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [Compartment:917758] clathrin-sculpted gamma-aminobutyric acid transport vesicle
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10857537
displayName	Synthesis of GABA by GAD2
eventOf	[Pathway:R-DME-888568] GABA synthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-888577] Synthesis of GABA by GAD2 - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Synthesis of GABA by GAD2
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-352011] GABA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-888577
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-888568] GABA synthesis
(precedingEvent)	[Reaction:R-DME-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen
(inferredTo)	[Reaction:R-HSA-888577] Synthesis of GABA by GAD2