RUNX2 binds the IHH gene promoter

Stable Identifier
R-HSA-8878257
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX2 binds the IHH gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, RUNX2, presumably associated with CBFB, binds the evolutionarily conserved RUNX2 response elements in the promoter of the IHH (Indian hedgehog) gene (Yoshida et al. 2004).

Literature References
PubMed ID Title Journal Year
15107406 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

Yoshida, CA, Yamamoto, H, Fujita, T, Furuichi, T, Ito, K, Inoue, K, Yamana, K, Zanma, A, Takada, K, Ito, Y, Komori, T

Genes Dev. 2004
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Runx2 binds the Ihh gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2016-06-30)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-06-30)
Cite Us!