RUNX2:MAF complex binds the BGLAP gene promoter

Stable Identifier
R-HSA-8877918
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2:MAF complex binds the BGLAP gene promoter
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RUNX2 binds the OSE2 element in the promoter of the BGLAP (osteocalcin, OC) gene. Formation of the complex between the activated androgen receptor (AR) and RUNX2 prevents RUNX2 from binding the BGLAP gene promoter (Baniwal et al. 2009). Based on studies in mice, RUNX2 binds to the BGLAP promoter in complex with the MAF transcription factor, and RUNX2 and MAF act synergistically to induce BGLAP transcription (Nishikawa et al. 2010). RUNX2 binding sites are conserved in the human BGLAP gene promoter.
Literature References
PubMed ID Title Journal Year
19389811 Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA

Coetzee, GA, Baniwal, SK, Khalid, O, Frenkel, B, Buchanan, G, Sir, D

Mol. Endocrinol. 2009
20877012 Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation

Takeda, S, Hamada, M, Yamaguchi, A, Kimura, A, Takayanagi, H, Nakashima, T, Takahashi, S, Isogai, M, Nishikawa, K, Owen, MJ, Kodama, T

J. Clin. Invest. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX2:AR:androgen [nucleoplasm] (Homo sapiens)
Active Unit
AR:androgens [nucleoplasm]
Inferred From
Runx2:Maf binds the Bglap gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2016-06-28)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-06-28)
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