RUNX2 binds the OSE2 element in the promoter of the BGLAP (osteocalcin, OC) gene. Formation of the complex between the activated androgen receptor (AR) and RUNX2 prevents RUNX2 from binding the BGLAP gene promoter (Baniwal et al. 2009). Based on studies in mice, RUNX2 binds to the BGLAP promoter in complex with the MAF transcription factor, and RUNX2 and MAF act synergistically to induce BGLAP transcription (Nishikawa et al. 2010). RUNX2 binding sites are conserved in the human BGLAP gene promoter.
Coetzee, GA, Baniwal, SK, Khalid, O, Frenkel, B, Buchanan, G, Sir, D
Takeda, S, Hamada, M, Yamaguchi, A, Kimura, A, Takayanagi, H, Nakashima, T, Takahashi, S, Isogai, M, Nishikawa, K, Owen, MJ, Kodama, T
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