Reactome | CBLL1 binds SRC-phosphorylated CDH1 complex

Schema > Reaction > Entries

CBLL1 binds SRC-phosphorylated CDH1 complex Show undefined attributes

authored	[InstanceEdit:8876400] Orlic-Milacic, Marija, 2016-06-14
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:25409] peptidoglycan-based cell wall [Compartment:70101] cytosol
created	[InstanceEdit:8876977] Orlic-Milacic, Marija, 2016-06-17
crossReference	[DatabaseIdentifier:12020818] Mondo:0005828
dbId	8876993
disease	[Disease:8875363] listeriosis
displayName	CBLL1 binds SRC-phosphorylated CDH1 complex
edited	[InstanceEdit:8943577] Orlic-Milacic, Marija, 2016-10-26
entityOnOtherCell	[EntityWithAccessionedSequence:R-LMO-8876505] InlA [peptidoglycan-based cell wall] - Listeria monocytogenes
eventOf	[Pathway:R-HSA-8876493] InlA-mediated entry of Listeria monocytogenes into host cells - Homo sapiens
followingEvent	[Reaction:R-HSA-8877003] CBLL1 ubiqutinates the InlA-bound CDH1 complex - Homo sapiens
input	[Complex:R-HSA-8876991] CBLL1 dimer:Zn2+ [cytosol] [Complex:R-HSA-8876941] InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CTNND1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8876973] Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
maxDepth	1
modified	[InstanceEdit:9836317] D'Eustachio, Peter, 2023-05-25
name	CBLL1 binds SRC-phosphorylated CDH1 complex Hakai binds SRC-phosphorylated E-cadherin complex
output	[EntityWithAccessionedSequence:R-HSA-418996] CTNND1 [plasma membrane] [Complex:R-HSA-8876983] InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-8876948] SRC phosphorylates InlA-bound CDH1 and CTNNB1 - Homo sapiens
relatedSpecies	[Species:8875362] Listeria monocytogenes
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8943564] Schwerk, Christian, 2016-10-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876993
summation	[Summation:8876997] CBL-like E3 ubiquitin ligase Hakai (CBLL1) binds to SRC-phos...

Referrals

(precedingEvent)	[Reaction:R-HSA-8877003] CBLL1 ubiqutinates the InlA-bound CDH1 complex
(hasEvent)	[Pathway:R-HSA-8876493] InlA-mediated entry of Listeria monocytogenes into host cells

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