CBLL1 binds SRC-phosphorylated CDH1 complex

Stable Identifier
R-HSA-8876993
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, cell wall, cytosol
Synonyms
Hakai binds SRC-phosphorylated E-cadherin complex
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CBLL1 binds SRC-phosphorylated CDH1 complex
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CBL-like E3 ubiquitin ligase Hakai (CBLL1) binds to SRC-phosphorylated E-cadherin (CDH1) complex bound to Listeria monocytogenes cell wall protein InlA (Bonazzi et al. 2008). SRC-mediated phosphorylation of CDH1 complex on tyrosine residues Y753 and Y754 of CDH1 and an unknown tyrosine of beta-catenin (CTNNB1) at cell-cell adhesion sites creates docking sites for CBLL1. CBLL1 functions as zinc (Zn2+) coordinated homodimer. While CBLL1 interacts simultaneously with CDH1 and CTNNB1, CTNND1 (p120 catenin) is displaced by CBLL1 binding (Fujita et al. 2002, Mukherjee et al. 2012).

Literature References
PubMed ID Title Journal Year
18624796 Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes

Pizarro-Cerdá, J, Bonazzi, M, Veiga, E, Cossart, P

Cell. Microbiol. 2008
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-17)
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