Reactome | RAPGEF1 activates RAP1

RAPGEF1 activates RAP1

Stable Identifier

R-HSA-8875568

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The level of activated (GTP-bound) RAP1 increases rapidly after HGF stimulation. The recruitment of RAPGEF1 (C3G) to CRK or CRKL bound to MET-phosphorylated GAB1 brings RAPGEF1 to the plasma membrane, where it can act on its substrate, RAP1, catalyzing guanine nucleotide exchange from GDP to GTP (Sakkab et al. 2000, Lamorte et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
10753869	Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL Sakkab, D, Lewitzky, M, Posern, G, Schaeper, U, Sachs, M, Birchmeier, W, Feller, SM	J. Biol. Chem.	2000
12006644	Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions Lamorte, L, Royal, I, Naujokas, M, Park, M	Mol. Biol. Cell	2002