RAPGEF1 activates RAP1

Stable Identifier
R-HSA-8875568
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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RAPGEF1 activates RAP1
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The level of activated (GTP-bound) RAP1 increases rapidly after HGF stimulation. The recruitment of RAPGEF1 (C3G) to CRK or CRKL bound to MET-phosphorylated GAB1 brings RAPGEF1 to the plasma membrane, where it can act on its substrate, RAP1, catalyzing guanine nucleotide exchange from GDP to GTP (Sakkab et al. 2000, Lamorte et al. 2002).

Literature References
PubMed ID Title Journal Year
12006644 Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

Lamorte, L, Royal, I, Naujokas, M, Park, M

Mol. Biol. Cell 2002
10753869 Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

Sakkab, D, Lewitzky, M, Posern, G, Schaeper, U, Sachs, M, Birchmeier, W, Feller, SM

J. Biol. Chem. 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]
Physical Entity
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
RAPGEF1 activates RAP1 (Caenorhabditis elegans)
RAPGEF1 activates RAP1 (Canis familiaris)
RAPGEF1 activates RAP1 (Danio rerio)
RAPGEF1 activates RAP1 (Gallus gallus)
RAPGEF1 activates RAP1 (Mus musculus)
RAPGEF1 activates RAP1 (Rattus norvegicus)
RAPGEF1 activates RAP1 (Sus scrofa)
RAPGEF1 activates RAP1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-06-08)