RAPGEF1 activates RAP1

Stable Identifier
R-HSA-8875568
Type
Reaction
Species
Homo sapiens
Compartment
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The level of activated (GTP-bound) RAP1 increases rapidly after HGF stimulation. The recruitment of RAPGEF1 (C3G) to CRK or CRKL bound to MET-phosphorylated GAB1 brings RAPGEF1 to the plasma membrane, where it can act on its substrate, RAP1, catalyzing guanine nucleotide exchange from GDP to GTP (Sakkab et al. 2000, Lamorte et al. 2002).

Literature References
PubMed ID Title Journal Year
10753869 Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

Lewitzky, M, Sakkab, D, Posern, G, Feller, SM, Birchmeier, W, Sachs, M, Schaeper, U

J. Biol. Chem. 2000
12006644 Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

Lamorte, L, Naujokas, M, Park, M, Royal, I

Mol. Biol. Cell 2002
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]

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