Reactome | CBL binds MET

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CBL binds MET Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8874680] Orlic-Milacic, Marija, 2016-05-25
dbId	8874685
displayName	CBL binds MET
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6807004] Negative regulation of MET activity - Homo sapiens
followingEvent	[Reaction:R-HSA-8875451] MET phosphorylates CBL - Homo sapiens
input	[CandidateSet:R-HSA-8876356] CBL:GRB2,CBL [cytosol] [CandidateSet:R-HSA-8874682] HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8874693] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein [LiteratureReference:8874700] c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination [LiteratureReference:8874699] A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation [LiteratureReference:8875182] Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CBL binds MET
orthologousEvent	[Reaction:R-GGA-8874685] CBL binds MET - Gallus gallus [Reaction:R-DRE-8874685] CBL binds MET - Danio rerio [Reaction:R-SSC-8874685] CBL binds MET - Sus scrofa [Reaction:R-BTA-8874685] CBL binds MET - Bos taurus [Reaction:R-CFA-8874685] CBL binds MET - Canis familiaris [Reaction:R-RNO-8874685] CBL binds MET - Rattus norvegicus [Reaction:R-MMU-8874685] CBL binds MET - Mus musculus
output	[CandidateSet:R-HSA-8876353] HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]
precedingEvent	[Reaction:R-HSA-6806974] MET dimers autophosphorylate - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8874685
summation	[Summation:8875085] The E3 ubiquitin ligase CBL can bind to the MET receptor eit...

Referrals

(hasEvent)	[Pathway:R-HSA-6807004] Negative regulation of MET activity
(precedingEvent)	[Reaction:R-HSA-8875451] MET phosphorylates CBL