Reactome | CBL binds MET

CBL binds MET

Stable Identifier

R-HSA-8874685

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The E3 ubiquitin ligase CBL can bind to the MET receptor either indirectly, through GRB2, or directly, through phosphorylated tyrosine Y1003 of MET (Peschard et al. 2001, Taher et al. 2002, Peschard et al. 2004). The kinase responsible for Y1003 phosphorylation is not known. Y1003 has not been reported as a MET autophosphorylation site, and is implicated as a possible PKC-alpha target (Zhao et al. 2013). As CBL-mediated ubiquitination of MET happens in response to HGF stimulation (Taher et al. 2002, Abella et al. 2005), it is likely that MET autophosphorylation precedes MET phosphorylation at Y1003.

Literature References

PubMed ID	Title	Journal	Year
15123609	A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation Peschard, P, Lipkowitz, S, Ishiyama, N, Park, M, Lin, T	J. Biol. Chem.	2004
12244174	c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination Borst, J, Spaargaren, M, Beuling, EA, Pals, ST, Taher, TE, Tjin, EP	J. Immunol.	2002
16227611	Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation Peschard, P, Naujokas, MA, Abella, JV, Saucier, C, Park, M, Urbé, S, Lin, T	Mol. Cell. Biol.	2005
11741535	Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein Band, H, Peschard, P, Naujokas, MA, Fournier, TM, Park, M, Lamorte, L, Langdon, WY	Mol. Cell	2001