Reactome | MET phosphorylates PTK2

Schema > Reaction > Entries

MET phosphorylates PTK2 Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8874604] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8874077] Orlic-Milacic, Marija, 2016-05-20
dbId	8874082
displayName	MET phosphorylates PTK2
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8874081] MET activates PTK2 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8874080] SRC phosphorylates PTK2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8874097] HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8874543] Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MET phosphorylates PTK2
orthologousEvent	[Reaction:R-CEL-8874082] MET phosphorylates PTK2 - Caenorhabditis elegans [Reaction:R-GGA-8874082] MET phosphorylates PTK2 - Gallus gallus [Reaction:R-XTR-8874082] MET phosphorylates PTK2 - Xenopus tropicalis [Reaction:R-DRE-8874082] MET phosphorylates PTK2 - Danio rerio [Reaction:R-SSC-8874082] MET phosphorylates PTK2 - Sus scrofa [Reaction:R-BTA-8874082] MET phosphorylates PTK2 - Bos taurus [Reaction:R-CFA-8874082] MET phosphorylates PTK2 - Canis familiaris [Reaction:R-RNO-8874082] MET phosphorylates PTK2 - Rattus norvegicus [Reaction:R-MMU-8874082] MET phosphorylates PTK2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8874601] HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]
precedingEvent	[Reaction:R-HSA-8874083] p-Y397-PTK2 binds SRC - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8874082
summation	[Summation:8874606] Activated MET phosphorylates PTK2 (FAK1) at tyrosine residue...

Referrals

(hasEvent)	[Pathway:R-HSA-8874081] MET activates PTK2 signaling
(precedingEvent)	[Reaction:R-HSA-8874080] SRC phosphorylates PTK2