MET phosphorylates PTK2

Stable Identifier
R-HSA-8874082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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MET phosphorylates PTK2
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Activated MET phosphorylates PTK2 (FAK1) at tyrosine residue Y194. Phosphorylation of PTK2 at Y194 facilitates SRC-mediated phosphorylation of PTK2 at Y577, but it has not been tested whether MET-mediated phosphorylation precedes SRC binding. MET may also phosphorylate PTK2 at Y5, although no functional significance of Y5 phosphorylation has been demonstrated. Activated EGFR and PDGFR can also phosphorylate PTK2 at Y5 and Y194 (Chen et al. 2011).
Literature References
PubMed ID Title Journal Year
20802513 Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

Chen, TH, Chan, PC, Chen, CL, Chen, HC

Oncogene 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]

Physical Entity
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
MET phosphorylates PTK2 (Bos taurus)
MET phosphorylates PTK2 (Caenorhabditis elegans)
MET phosphorylates PTK2 (Canis familiaris)
MET phosphorylates PTK2 (Danio rerio)
MET phosphorylates PTK2 (Gallus gallus)
MET phosphorylates PTK2 (Mus musculus)
MET phosphorylates PTK2 (Rattus norvegicus)
MET phosphorylates PTK2 (Sus scrofa)
MET phosphorylates PTK2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-05-20)
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