Activated MET phosphorylates PTK2 (FAK1) at tyrosine residue Y194. Phosphorylation of PTK2 at Y194 facilitates SRC-mediated phosphorylation of PTK2 at Y577, but it has not been tested whether MET-mediated phosphorylation precedes SRC binding. MET may also phosphorylate PTK2 at Y5, although no functional significance of Y5 phosphorylation has been demonstrated. Activated EGFR and PDGFR can also phosphorylate PTK2 at Y5 and Y194 (Chen et al. 2011).