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Schema
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Pathway
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Entries
MET activates PTK2 signaling
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authored
[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created
[InstanceEdit:8874077] Orlic-Milacic, Marija, 2016-05-20
crossReference
[DatabaseIdentifier:12325476] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
dbId
8874081
displayName
MET activates PTK2 signaling
edited
[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf
[Pathway:R-HSA-8875878] MET promotes cell motility - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-8874079] PTK2 binds activated MET - Homo sapiens
[Reaction:R-HSA-8874078] PTK2 autophosphorylates - Homo sapiens
[Reaction:R-HSA-8874083] p-Y397-PTK2 binds SRC - Homo sapiens
[Reaction:R-HSA-8874082] MET phosphorylates PTK2 - Homo sapiens
[Reaction:R-HSA-8874080] SRC phosphorylates PTK2 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8874536] HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells
[LiteratureReference:8874535] Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
[LiteratureReference:8874555] The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant
[LiteratureReference:8874553] FAK dimerization controls its kinase-dependent functions at focal adhesions
[LiteratureReference:8874559] Structural basis for the autoinhibition of focal adhesion kinase
[LiteratureReference:8874543] Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
MET activates PTK2 signaling
orthologousEvent
[Pathway:R-GGA-8874081] MET activates PTK2 signaling - Gallus gallus
[Pathway:R-CEL-8874081] MET activates PTK2 signaling - Caenorhabditis elegans
[Pathway:R-SSC-8874081] MET activates PTK2 signaling - Sus scrofa
[Pathway:R-BTA-8874081] MET activates PTK2 signaling - Bos taurus
[Pathway:R-CFA-8874081] MET activates PTK2 signaling - Canis familiaris
[Pathway:R-RNO-8874081] MET activates PTK2 signaling - Rattus norvegicus
[Pathway:R-MMU-8874081] MET activates PTK2 signaling - Mus musculus
releaseDate
2016-09-19
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11
[InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8874081
summation
[Summation:8875921] MET receptor activates the focal adhesion kinase PTK2 (FAK1)...
Referrals
(hasEvent)
[Pathway:R-HSA-8875878] MET promotes cell motility
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