USP4 deubiquitinate TRAF2,TRAF6

Stable Identifier
R-HSA-8869456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP4 specifically interacts with tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and TRAF6 but not TRAF3. It deubiquitinates both TRAF2 and TRAF6 in vivo and in vitro, negatively regulating TNFalpha and IL-1beta-induced NF-kappaB activation and cancer cell migration (Xiao et al. 2012). USP25, a negative regulator of the virus-triggered type I IFN signaling pathway, cleaves lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo from DDX58 (Retinoic acid-inducible gene I (RIG-I)), TRAF2, and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling (Zhong et al. 2013).

Literature References
PubMed ID Title Journal Year
22029577 Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF╬▒-induced cancer cell migration

Xiao, N, Li, H, Luo, J, Wang, R, Chen, H, Chen, J, Wang, P

Biochem. J. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP4 [cytosol]
Physical Entity
Activity
Orthologous Events
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