TBC1 domain family member 3 (TBC1D3) belongs to the TBC/RabGAPs family and contains a TBC (Tre-2/Bub2/Cdc16) domain but has no GAP activity. It regulates macropinocytosis in response to epidermal growth factor (EGF), and facilitates crosstalk between the GTPases ARF6 and RAB5 (Frittoli et al. 2008). TBC1D3 binds to the ARF6 effector protein GGA (Golgi-localized, gamma-ear-containing, ARF-binding protein), which binds to a complex consisting of the RAB5GEF, rabaptin 5-associated exchange factor for Rab5 (RABEX5), and the Rab5 effector Rabaptin-5, thereby providing an indirect interaction between TBC1D3 and RAB5. Although TBC1D3 associates with Rab5, it may operate as a Rab5 effector, and not as a Rab5 GAP (Huaiping et al. 2007, Wainszelbaum et al. 2008).
Kirkpatrick, DS, Kong, C, Srikanth, P, Wainszelbaum, MJ, Gygi, SP, Barbieri, MA, Charron, AJ, Stahl, PD
Fukuda, M, Pizzigoni, A, Di Fiore, PP, Palamidessi, A, Scita, G, Troglio, F, Troilo, A, Frittoli, E, Garrè, M, Confalonieri, S, Lanzetti, L
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