Reactome | SCF-FBXL18 ubiquitinates FBXL7

Schema > Reaction > Entries

SCF-FBXL18 ubiquitinates FBXL7 Show undefined attributes

authored	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
catalystActivity	[CatalystActivity:8854055] ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643346] ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol] F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
dbId	8854051
displayName	SCF-FBXL18 ubiquitinates FBXL7
edited	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
eventOf	[Pathway:R-HSA-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160433] SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
input	[EntityWithAccessionedSequence:R-HSA-8854032] FBXL7 [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854057] F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SCF-FBXL18 ubiquitinates FBXL7
negativePrecedingEvent	[NegativePrecedingEvent:9764022] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53 [NegativePrecedingEvent:9764048] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764047] Futile Cycle: Proteasome-mediated degradation of PolyUb-FBXL7
orthologousEvent	[Reaction:R-DDI-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Dictyostelium discoideum [Reaction:R-CEL-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Caenorhabditis elegans [Reaction:R-DME-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Drosophila melanogaster [Reaction:R-DRE-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Danio rerio [Reaction:R-BTA-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Bos taurus [Reaction:R-CFA-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Canis familiaris [Reaction:R-RNO-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Rattus norvegicus [Reaction:R-MMU-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8854053] PolyUb-K109-FBXL7 [cytosol]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8874675] Grant, Rhys, 2016-05-13 [InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854051
summation	[Summation:8854056] FBXL18, a substrate recognition subunit of the SCF E3 ubiqui...
updateTrackers	[UpdateTracker:9778543] Update Tracker - [Reaction:8854051] SCF-FBXL18 ubiquitinates FBXL7 - v68:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778543] Update Tracker - [Reaction:8854051] SCF-FBXL18 ubiquitinates FBXL7 - v68:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
(precedingEvent)	[BlackBoxEvent:R-HSA-8854071] Proteasome-mediated degradation of PolyUb-FBXL7