Reactome | SCF-FBXL18 ubiquitinates FBXL7

Schema > Reaction > Entries

SCF-FBXL18 ubiquitinates FBXL7 Show undefined attributes

catalystActivity	[CatalystActivity:11037776] ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11037778
displayName	SCF-FBXL18 ubiquitinates FBXL7
eventOf	[Pathway:R-DDI-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Dictyostelium discoideum
goBiologicalProcess	[GO_BiologicalProcess:160433] SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
inferredFrom	[Reaction:R-HSA-8854051] SCF-FBXL18 ubiquitinates FBXL7 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DDI-8854032] FBXL7 [cytosol] 3 × [DefinedSet:R-DDI-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF-FBXL18 ubiquitinates FBXL7
output	[EntityWithAccessionedSequence:R-DDI-8854053] PolyUb-K109-FBXL7 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8854051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
(precedingEvent)	[BlackBoxEvent:R-DDI-8854071] Proteasome-mediated degradation of PolyUb-FBXL7
(inferredTo)	[Reaction:R-HSA-8854051] SCF-FBXL18 ubiquitinates FBXL7

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