Reactome | Plasma membrane FGFR1 fusions dimerize

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Plasma membrane FGFR1 fusions dimerize Show undefined attributes

authored	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8853327] Rothfels, Karen, 2016-01-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	8853322
disease	[Disease:1500689] cancer
displayName	Plasma membrane FGFR1 fusions dimerize
edited	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
entityFunctionalStatus	[EntityFunctionalStatus:8853292] gain_of_function of plasma membrane FGFR1 fusions [plasma membrane]
eventOf	[Pathway:R-HSA-8853336] Signaling by plasma membrane FGFR1 fusions - Homo sapiens
followingEvent	[Reaction:R-HSA-8853325] Plasma membrane FGFR1 fusions autophosphorylate - Homo sapiens
input	2 × [CandidateSet:R-HSA-8853277] plasma membrane FGFR1 fusions [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8853053] Transforming fusions of FGFR and TACC genes in human glioblastoma [LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers [LiteratureReference:8852927] FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Plasma membrane FGFR1 fusions dimerize
output	[CandidateSet:R-HSA-8853271] Plasma membrane FGFR1 fusion dimers [plasma membrane]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8853322
summation	[Summation:8853068] Although dimerization of the FGFR1 fusions in glioblastoma, ...

Referrals

(hasEvent)	[Pathway:R-HSA-8853336] Signaling by plasma membrane FGFR1 fusions
(precedingEvent)	[Reaction:R-HSA-8853325] Plasma membrane FGFR1 fusions autophosphorylate

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