Plasma membrane FGFR1 fusions dimerize

Stable Identifier
R-HSA-8853322
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Although dimerization of the FGFR1 fusions in glioblastoma, breast cancer and non small cell lung cancer hasn't been directly demonstrated, the ability of these proteins to promote transformation and tumorigenesis suggests that they form active oligomers as is the case for WT FGFR1 proteins (Singh et al, 2012; Wang et al, 2013; Wang et al, 2014; reviewed in Parker et al, 2014).

Literature References
PubMed ID Title Journal Year
22837387 Transforming fusions of FGFR and TACC genes in human glioblastoma

Singh, D, Chan, JM, Zoppoli, P, Niola, F, Sullivan, R, Castano, A, Liu, EM, Reichel, J, Porrati, P, Pellegatta, S, Qiu, K, Gao, Z, Ceccarelli, M, Riccardi, R, Brat, DJ, Guha, A, Aldape, K, Golfinos, JG, Zagzag, D, Mikkelsen, T, Finocchiaro, G, Lasorella, A, Rabadan, R, Iavarone, A

Science 2012
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
24850843 FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer

Wang, R, Wang, L, Li, Y, Hu, H, Shen, L, Shen, X, Pan, Y, Ye, T, Zhang, Y, Luo, X, Zhang, Y, Pan, B, Li, B, Li, H, Zhang, J, Pao, W, Ji, H, Sun, Y, Chen, H

Clin. Cancer Res. 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
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