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Schema
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Reaction
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Entries
NTPDase8 hydrolyzes nucleoside diphosphates
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authored
[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
catalystActivity
[CatalystActivity:8851544] nucleoside diphosphate phosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9644003] nucleoside-diphosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane] Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:8851548] Orlic-Milacic, Marija, 2016-01-06
crossReference
[DatabaseIdentifier:12667810] RHEA:64961
[DatabaseIdentifier:9976509] RHEA:61437
[DatabaseIdentifier:9976529] RHEA:22157
[DatabaseIdentifier:9976351] RHEA:35208
[DatabaseIdentifier:9976519] RHEA:64881
[DatabaseIdentifier:9976508] RHEA:64961
[DatabaseIdentifier:9976506] RHEA:64877
dbId
8851550
displayName
NTPDase8 hydrolyzes nucleoside diphosphates
edited
[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
eventOf
[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins - Homo sapiens
input
[DefinedSet:R-ALL-9726189] ADP,GDP,IDP,CDP,TDP,UDP [extracellular region]
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8851551] Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8
[LiteratureReference:8871010] Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase
[LiteratureReference:8871016] Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
NTPDase8 hydrolyzes nucleoside diphosphates
ADP + H2O => AMP + phosphate + H(+)
GDP + H2O => GMP + phosphate + H(+)
IDP + H2O => IMP + phosphate + H(+)
CDP + H2O => CMP + phosphate + H(+)
dTDP + H2O => dTMP + phosphate + H(+)
UDP + H2O => UMP + phosphate + H(+)
orthologousEvent
[Reaction:R-PFA-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Plasmodium falciparum
[Reaction:R-SCE-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Saccharomyces cerevisiae
[Reaction:R-SPO-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Schizosaccharomyces pombe
[Reaction:R-GGA-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Gallus gallus
[Reaction:R-XTR-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Xenopus tropicalis
[Reaction:R-DRE-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Danio rerio
[Reaction:R-SSC-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Sus scrofa
[Reaction:R-BTA-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Bos taurus
[Reaction:R-CFA-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Canis familiaris
[Reaction:R-RNO-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Rattus norvegicus
[Reaction:R-MMU-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Mus musculus
output
[DefinedSet:R-ALL-9726186] AMP,GMP,IMP,CMP,TMP,UMP [extracellular region]
[SimpleEntity:R-ALL-351626] H+ [extracellular region]
[SimpleEntity:R-ALL-109277] Pi [extracellular region]
precedingEvent
[Reaction:R-HSA-8851538] NTPDase8 hydrolyzes nucleoside triphosphates - Homo sapiens
releaseDate
2016-06-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8870674] Sévigny, Jean, 2016-05-10
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8851550
summation
[Summation:8851560] NTPDase8, encoded by the ENTPD8 gene, is the main liver ecto...
updateTrackers
[UpdateTracker:9776220] Update Tracker - [Reaction:8851550] NTPDase8 hydrolyzes nucleoside diphosphates - v77:[add_removeInput, add_removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9776220] Update Tracker - [Reaction:8851550] NTPDase8 hydrolyzes nucleoside diphosphates - v77:[add_removeInput, add_removeOutput]
(hasEvent)
[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins
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