NTPDase8 hydrolyzes nucleoside diphosphates

Stable Identifier
R-HSA-8851550
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NTPDase8, encoded by the ENTPD8 gene, is the main liver ectonucleotide phosphatase. NTPDase8 belongs to the E-NTPDase family of nucleotide phosphatases and can hydrolyze NDPs to corresponding NMPs (Sévigny et al. 2000, Bigonnesse et al. 2004, Fausther et al. 2007).

Literature References
PubMed ID Title Journal Year
17095758 Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8

Fausther, M, Lecka, J, Kukulski, F, Lévesque, SA, Pelletier, J, Zimmermann, H, Dranoff, JA, Sévigny, J

Am. J. Physiol. Gastrointest. Liver Physiol. 2007
15122917 Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8

Bigonnesse, F, Lévesque, SA, Kukulski, F, Lecka, J, Robson, SC, Fernandes, MJ, Sévigny, J

Biochemistry 2004
10681547 Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase

Sévigny, J, Robson, SC, Waelkens, E, Csizmadia, E, Smith, RN, Lemmens, R

J. Biol. Chem. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside-diphosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created