NTPDase8 hydrolyzes nucleoside diphosphates

Stable Identifier
R-HSA-8851550
Type
Reaction
Species
Homo sapiens
Compartment
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NTPDase8, encoded by the ENTPD8 gene, is the main liver ectonucleotide phosphatase. NTPDase8 belongs to the E-NTPDase family of nucleotide phosphatases and can hydrolyze NDPs to corresponding NMPs (Sévigny et al. 2000, Bigonnesse et al. 2004, Fausther et al. 2007).

Literature References
PubMed ID Title Journal Year
15122917 Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8

Lecka, J, Sévigny, J, Kukulski, F, Robson, SC, Lévesque, SA, Bigonnesse, F, Fernandes, MJ

Biochemistry 2004
17095758 Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8

Sévigny, J, Pelletier, J, Lecka, J, Dranoff, JA, Kukulski, F, Fausther, M, Lévesque, SA, Zimmermann, H

Am. J. Physiol. Gastrointest. Liver Physiol. 2007
10681547 Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase

Csizmadia, E, Sévigny, J, Smith, RN, Robson, SC, Lemmens, R, Waelkens, E

J. Biol. Chem. 2000
Participants
Participates
Catalyst Activity

nucleoside-diphosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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