Reactome | NTPDase8 hydrolyzes nucleoside diphosphates

NTPDase8 hydrolyzes nucleoside diphosphates

Stable Identifier

R-HSA-8851550

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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NTPDase8 hydrolyzes nucleoside diphosphates

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NTPDase8, encoded by the ENTPD8 gene, is the main liver ectonucleotide phosphatase. NTPDase8 belongs to the E-NTPDase family of nucleotide phosphatases and can hydrolyze NDPs to corresponding NMPs (Sévigny et al. 2000, Bigonnesse et al. 2004, Fausther et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
15122917	Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8 Lecka, J, Sévigny, J, Kukulski, F, Robson, SC, Lévesque, SA, Bigonnesse, F, Fernandes, MJ	Biochemistry	2004
17095758	Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8 Sévigny, J, Pelletier, J, Lecka, J, Dranoff, JA, Kukulski, F, Fausther, M, Lévesque, SA, Zimmermann, H	Am. J. Physiol. Gastrointest. Liver Physiol.	2007
10681547	Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase Csizmadia, E, Sévigny, J, Smith, RN, Robson, SC, Lemmens, R, Waelkens, E	J. Biol. Chem.	2000