Reactome | NTPDase8 hydrolyzes nucleoside diphosphates

Schema > Reaction > Entries

NTPDase8 hydrolyzes nucleoside diphosphates Show undefined attributes

catalystActivity	[CatalystActivity:10712535] nucleoside diphosphate phosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10712537
displayName	NTPDase8 hydrolyzes nucleoside diphosphates
eventOf	[Pathway:R-XTR-8850843] Phosphate bond hydrolysis by NTPDase proteins - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Homo sapiens
input	[DefinedSet:R-ALL-9726189] ADP,GDP,IDP,CDP,TDP,UDP [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	NTPDase8 hydrolyzes nucleoside diphosphates ADP + H2O => AMP + phosphate + H(+) GDP + H2O => GMP + phosphate + H(+) IDP + H2O => IMP + phosphate + H(+) CDP + H2O => CMP + phosphate + H(+) dTDP + H2O => dTMP + phosphate + H(+) UDP + H2O => UMP + phosphate + H(+)
output	[DefinedSet:R-ALL-9726186] AMP,GMP,IMP,CMP,TMP,UMP [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
precedingEvent	[Reaction:R-XTR-8851538] NTPDase8 hydrolyzes nucleoside triphosphates - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8851550
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8850843] Phosphate bond hydrolysis by NTPDase proteins
(inferredTo)	[Reaction:R-HSA-8851550] NTPDase8 hydrolyzes nucleoside diphosphates

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