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Entries
NTPDase6 hydrolyzes nucleoside diphosphates
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authored
[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
catalystActivity
[CatalystActivity:8851466] nucleoside diphosphate phosphatase activity of NTPDase6:Ca2+,Mg2+ [extracellular region]
catalystActivityReference
[CatalystActivityReference:9644041] nucleoside-diphosphatase activity of NTPDase6:Ca2+,Mg2+ [extracellular region] Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function
category
transition
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:8851394] Orlic-Milacic, Marija, 2016-01-06
crossReference
[DatabaseIdentifier:9976529] RHEA:22157
[DatabaseIdentifier:9976351] RHEA:35208
[DatabaseIdentifier:9976506] RHEA:64877
[DatabaseIdentifier:9976519] RHEA:64881
dbId
8851396
displayName
NTPDase6 hydrolyzes nucleoside diphosphates
edited
[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
eventOf
[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins - Homo sapiens
input
[DefinedSet:R-ALL-8851462] CDP,GDP,IDP,UDP [extracellular region]
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8851393] CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart
[LiteratureReference:8851391] Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function
[LiteratureReference:8851460] Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2)
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
NTPDase6 hydrolyzes nucleoside diphosphates
GDP + H2O => GMP + phosphate + H(+)
IDP + H2O => IMP + phosphate + H(+)
UDP + H2O => UMP + phosphate + H(+)
CDP + H2O => CMP + phosphate + H(+)
orthologousEvent
[Reaction:R-PFA-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Plasmodium falciparum
[Reaction:R-CEL-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Caenorhabditis elegans
[Reaction:R-DME-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Drosophila melanogaster
[Reaction:R-GGA-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Gallus gallus
[Reaction:R-XTR-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Xenopus tropicalis
[Reaction:R-DRE-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Danio rerio
[Reaction:R-SSC-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Sus scrofa
[Reaction:R-BTA-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Bos taurus
[Reaction:R-CFA-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Canis familiaris
[Reaction:R-RNO-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Rattus norvegicus
[Reaction:R-MMU-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Mus musculus
output
[DefinedSet:R-ALL-8851461] CMP,GMP,IMP,UMP [extracellular region]
[SimpleEntity:R-ALL-351626] H+ [extracellular region]
[SimpleEntity:R-ALL-109277] Pi [extracellular region]
releaseDate
2016-06-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8870674] Sévigny, Jean, 2016-05-10
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8851396
summation
[Summation:8851472] NTPDase6 (CD39L2), encoded by the ENTPD6 gene, is an ectonuc...
updateTrackers
[UpdateTracker:9775589] Update Tracker - [Reaction:8851396] NTPDase6 hydrolyzes nucleoside diphosphates - v78:[addOutput]
Referrals
(updatedInstance)
[UpdateTracker:9775589] Update Tracker - [Reaction:8851396] NTPDase6 hydrolyzes nucleoside diphosphates - v78:[addOutput]
(hasEvent)
[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins
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