Reactome | NTPDase6 hydrolyzes nucleoside diphosphates

Schema > Reaction > Entries

NTPDase6 hydrolyzes nucleoside diphosphates Show undefined attributes

catalystActivity	[CatalystActivity:10198344] nucleoside diphosphate phosphatase activity of NTPDase6:Ca2+,Mg2+ [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10198346
displayName	NTPDase6 hydrolyzes nucleoside diphosphates
eventOf	[Pathway:R-RNO-8850843] Phosphate bond hydrolysis by NTPDase proteins - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8851396] NTPDase6 hydrolyzes nucleoside diphosphates - Homo sapiens
input	[DefinedSet:R-ALL-8851462] CDP,GDP,IDP,UDP [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	NTPDase6 hydrolyzes nucleoside diphosphates GDP + H2O => GMP + phosphate + H(+) IDP + H2O => IMP + phosphate + H(+) UDP + H2O => UMP + phosphate + H(+) CDP + H2O => CMP + phosphate + H(+)
output	[DefinedSet:R-ALL-8851461] CMP,GMP,IMP,UMP [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8851396
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8850843] Phosphate bond hydrolysis by NTPDase proteins
(inferredTo)	[Reaction:R-HSA-8851396] NTPDase6 hydrolyzes nucleoside diphosphates

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