Reactome | NTPDase6 hydrolyzes nucleoside diphosphates

NTPDase6 hydrolyzes nucleoside diphosphates

Stable Identifier

R-HSA-8851396

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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NTPDase6 hydrolyzes nucleoside diphosphates

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NTPDase6 (CD39L2), encoded by the ENTPD6 gene, is an ectonucleotide phosphatase of the E-NTPDase family that can be secreted (Yeung et al. 2000). Secretion involves the removal of the first 77 amino acids at the N-terminus by an unknown peptidase. Secreted NTPDase6 hydrolyzes nucleoside diphosphates GDP, IDP and, less efficiently, UDP and CDP to nucleoside monophosphates GMP, IMP, UMP and CMP, respectively. Secreted NTPDase6 hydrolyzes ADP to AMP and nucleoside triphosphates GTP, ITP, UTP and CTP to corresponding nucleoside diphosphates with very low efficacy (Hicks-Berger et al. 2000, Yeung et al. 2000, Ivanenkov et al. 2003). NTPDase6 requires Ca2+ or Mg2+ for catalytic activity (Hicks-Berger et al. 2000, Ivanenkov et al. 2003).

NTPDase6 may also be able to function as a membrane-bound enzyme, but its catalytic rate is very low and accounts for up to 10% of NTPDase6 activity (Hicks-Berger et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
14529283	Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function Ivanenkov, VV, Murphy-Piedmonte, DM, Kirley, TL	Biochemistry	2003
11041856	CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart Yeung, G, Mulero, JJ, McGowan, DW, Bajwa, SS, Ford, JE	Biochemistry	2000
10948193	Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2) Hicks-Berger, CA, Chadwick, BP, Frischauf, AM, Kirley, TL	J. Biol. Chem.	2000