Reactome | IL18 binds IL18R1

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IL18 binds IL18R1 Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8848374] Jupe, Steve, 2015-12-08
dbId	8848370
displayName	IL18 binds IL18R1
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
eventOf	[Pathway:R-HSA-9012546] Interleukin-18 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8848395] IL18:IL18R1 binds IL18RAP - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-448446] IL18 [extracellular region] [EntityWithAccessionedSequence:R-HSA-197600] IL18R1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848361] Purification and characterization of the human interleukin-18 receptor
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	IL18 binds IL18R1
orthologousEvent	[Reaction:R-BTA-8848370] IL18 binds IL18R1 - Bos taurus [Reaction:R-XTR-8848370] IL18 binds IL18R1 - Xenopus tropicalis [Reaction:R-SSC-8848370] IL18 binds IL18R1 - Sus scrofa [Reaction:R-CFA-8848370] IL18 binds IL18R1 - Canis familiaris [Reaction:R-RNO-8848370] IL18 binds IL18R1 - Rattus norvegicus [Reaction:R-MMU-8848370] IL18 binds IL18R1 - Mus musculus
output	[Complex:R-HSA-8848366] IL18:IL18R1 [plasma membrane]
regulatedBy	[PositiveRegulation:R-HSA-9012512] Positive regulation by 'IL18-2(37-189) [extracellular region]' [NegativeRegulation:R-HSA-9012559] Negative regulation by 'IL18BP:IL18 [extracellular region]'
regulationReference	[RegulationReference:9641684] Negative regulation by 'IL18BP:IL18 [extracellular region]' Identification of amino acid residues critical for biological activity in human interleukin-18 [RegulationReference:9641912] Positive regulation by 'IL18-2(37-189) [extracellular region]' Induction of interferon-gamma inducing factor in the adrenal cortex
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8848370
summation	[Summation:8848400] Interleukin-18 (IL18) binds IL18 receptor alpha chain (IL18R...
updateTrackers	[UpdateTracker:9780617] Update Tracker - [Reaction:8848370] IL18 binds IL18R1 - v62:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780617] Update Tracker - [Reaction:8848370] IL18 binds IL18R1 - v62:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-9012546] Interleukin-18 signaling
(precedingEvent)	[Reaction:R-HSA-8848395] IL18:IL18R1 binds IL18RAP