Reactome | IL18 binds IL18R1

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IL18 binds IL18R1 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10306379
displayName	IL18 binds IL18R1
eventOf	[Pathway:R-CFA-9012546] Interleukin-18 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8848395] IL18:IL18R1 binds IL18RAP - Canis familiaris
inferredFrom	[Reaction:R-HSA-8848370] IL18 binds IL18R1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-448446] IL18 [extracellular region] [EntityWithAccessionedSequence:R-CFA-197600] IL18R1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL18 binds IL18R1
output	[Complex:R-CFA-8848366] IL18:IL18R1 [plasma membrane]
regulatedBy	[PositiveRegulation:10306380] Positive regulation by 'IL18-2(37-189) [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8848370
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9012546] Interleukin-18 signaling
(precedingEvent)	[Reaction:R-CFA-8848395] IL18:IL18R1 binds IL18RAP
(inferredTo)	[Reaction:R-HSA-8848370] IL18 binds IL18R1