Expression of DEC2 (BHLHE41, BHLHB3)

Stable Identifier
R-HSA-879770
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of DEC2 (BHLHE41, BHLHB3)
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The DEC2 (BHLHE41, BHLHB3) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds E-box elements in the DEC2 promoter and activates transcription of DEC2.
Literature References
PubMed ID Title Journal Year
11162494 Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins

Fujimoto, K, Shen, M, Noshiro, M, Matsubara, K, Shingu, S, Honda, K, Yoshida, E, Suardita, K, Matsuda, Y, Kato, Y

Biochem Biophys Res Commun 2001
12624110 DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter

Li, Y, Xie, M, Song, X, Gragen, S, Sachdeva, K, Wan, Y, Yan, B

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
BHLHE40 dimer [nucleoplasm] (Homo sapiens)
Positively by
Regulator
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Dec2 (Bhlhe41, Bhlhb3) (Mus musculus)
Authored
May, B  (2010-06-18)
Reviewed
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Delaunay, F  (2010-06-23)
Albrecht, U  (2025-03-07)
Created
May, B  (2010-06-23)
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