Reactome | Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2

Schema > Reaction > Entries

Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 Show undefined attributes

catalystActivity	[CatalystActivity:77317] acyl-CoA dehydrogenase activity of ACADS tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667516] RHEA:31208 [DatabaseIdentifier:9977737] RHEA:31208
dbId	77327
displayName	Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2
eventOf	[Pathway:R-HSA-77350] Beta oxidation of hexanoyl-CoA to butanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77325] trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA - Homo sapiens [Reaction:R-HSA-169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF - Homo sapiens
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-77326] HX-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77398] On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein. [LiteratureReference:70739] Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 hexanoyl-CoA + FAD + H(+) => (2E)-hexenoyl-CoA + FADH2
orthologousEvent	[Reaction:R-DRE-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Danio rerio [Reaction:R-DME-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Drosophila melanogaster [Reaction:R-GGA-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Gallus gallus [Reaction:R-XTR-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Xenopus tropicalis [Reaction:R-SSC-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Sus scrofa [Reaction:R-BTA-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Bos taurus [Reaction:R-CFA-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Canis familiaris [Reaction:R-RNO-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Rattus norvegicus [Reaction:R-MMU-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Mus musculus
output	[SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] [SimpleEntity:R-ALL-77324] trans-Hex-2-enoyl-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77327
summation	[Summation:178861] ACADS in the mitochondrial matrix dehydrogenates hexanoyl-Co...
updateTrackers	[UpdateTracker:9984663] Update Tracker - [Reaction:77327] Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 - v96:[modifyText, removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9984663] Update Tracker - [Reaction:77327] Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 - v96:[modifyText, removeInput]
(hasEvent)	[Pathway:R-HSA-77350] Beta oxidation of hexanoyl-CoA to butanoyl-CoA
(precedingEvent)	[Reaction:R-HSA-169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF [Reaction:R-HSA-77325] trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA