Reactome | 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA

Schema > Reaction > Entries

3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:77268] acetyl-CoA C-acyltransferase activity of Trifunctional Protein [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667515] RHEA:31205 [DatabaseIdentifier:9977738] RHEA:31205
dbId	77329
displayName	3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA
eventOf	[Pathway:R-HSA-77348] Beta oxidation of octanoyl-CoA to hexanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Homo sapiens
input	[SimpleEntity:R-ALL-77328] 3-Oxooctanoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77405] Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA 3-oxooctanoyl-CoA + CoA => hexanoyl-CoA + acetyl-CoA
orthologousEvent	[Reaction:R-DRE-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Danio rerio [Reaction:R-CEL-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Caenorhabditis elegans [Reaction:R-DME-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Drosophila melanogaster [Reaction:R-GGA-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Gallus gallus [Reaction:R-XTR-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Xenopus tropicalis [Reaction:R-SSC-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Sus scrofa [Reaction:R-BTA-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Bos taurus [Reaction:R-CFA-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Canis familiaris [Reaction:R-RNO-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Rattus norvegicus [Reaction:R-MMU-77329] 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-77326] HX-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77329
summation	[Summation:178341] Trifunctional protein in the mitochondrial matrix converts 3...
updateTrackers	[UpdateTracker:9984600] Update Tracker - [Reaction:77329] 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984600] Update Tracker - [Reaction:77329] 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-77348] Beta oxidation of octanoyl-CoA to hexanoyl-CoA
(precedingEvent)	[Reaction:R-HSA-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2