Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2

Stable Identifier
R-HSA-77327
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
hexanoyl-CoA + FAD + H(+) => (2E)-hexenoyl-CoA + FADH2
ReviewStatus
5/5
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Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ACADS in the mitochondrial matrix dehydrogenates hexanoyl-CoA to form trans-hex-2-enoyl-CoA. (Krane & Beinert 1956; Finocchiaro et al. 1987).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acyl-CoA dehydrogenase activity of ACADS tetramer [mitochondrial matrix]

Physical Entity
ACADS tetramer [mitochondrial matrix] (Homo sapiens)
Activity
acyl-CoA dehydrogenase activity (GO:0003995)
Orthologous Events
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Bos taurus)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Danio rerio)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Drosophila melanogaster)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Gallus gallus)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 (Xenopus tropicalis)
Cross References
RHEA
Reviewed
D'Eustachio, P  (2025-12-30)
Created
Gillespie, ME  (2003-09-19)
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