Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA

Stable Identifier
R-HSA-77314
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'Crotonoyl-CoA', and 1 molecule of 'H2O' are present. At the end of this reaction, 1 molecule of '(S)-3-Hydroxybutanoyl-CoA' is present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the 'enoyl-CoA hydratase activity' of 'enoyl-CoA hydratase hexamer'.

Literature References
PubMed ID Title Journal Year
13295248 Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.

Stern, JR, Del Campillo, A

J Biol Chem 1956
Participants
Input
Output
Participates
as an event of
Catalyst Activity

enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]

Physical Entity
ECHS1 hexamer [mitochondrial matrix] (Homo sapiens)
Activity
enoyl-CoA hydratase activity (GO:0004300)
Orthologous Events
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Danio rerio)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Rattus norvegicus)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)
Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Xenopus tropicalis)
Cross References
Rhea
Created
Gillespie, ME  (2003-09-19)
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