(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H

Stable Identifier
R-HSA-77303
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
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(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'NAD+', and 1 molecule of '(S)-3-Hydroxyhexadecanoyl-CoA' are present. At the end of this reaction, 1 molecule of '3-Oxopalmitoyl-CoA', 1 molecule of 'H+', and 1 molecule of 'NADH' are present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the '3-hydroxyacyl-CoA dehydrogenase activity' of 'Trifunctional Protein'.

Literature References
PubMed ID Title Journal Year
1550553 Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.

Carpenter, K, Pollitt, RJ, Middleton, B

Biochem Biophys Res Commun 1992
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
3-hydroxyacyl-CoA dehydrogenase activity of Trifunctional Protein [mitochondrial matrix]
Physical Entity
Trifunctional Protein [mitochondrial matrix]
Activity
3-hydroxyacyl-CoA dehydrogenase activity (0003857)
Orthologous Events
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Bos taurus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Gallus gallus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)
Cross References
Rhea
Created
Gillespie, ME  (2003-09-19)