(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H

Stable Identifier
R-HSA-77303
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + NADH + H(+)
ReviewStatus
5/5
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(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Trifunctional protein in the mitochondrial matrix dehydrogenates (S)-3-hydroxyhexadecanoyl-CoA to form 3-oxopalmitoyl-CoA (Carpenter et al. 1992).
Literature References
PubMed ID Title Journal Year
1550553 Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.

Carpenter, K, Pollitt, RJ, Middleton, B

Biochem Biophys Res Commun 1992
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Output
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as an event of
Catalyst Activity

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of Trifunctional Protein [mitochondrial matrix]

Physical Entity
Trifunctional Protein [mitochondrial matrix] (Homo sapiens)
Activity
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity (GO:0003857)
Orthologous Events
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Bos taurus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Danio rerio)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Gallus gallus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)
(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)
Cross References
RHEA
Created
Gillespie, ME  (2003-09-19)
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