Reactome | AMP + H2O => IMP + NH4+ (AMPD)

Schema > Reaction > Entries

AMP + H2O => IMP + NH4+ (AMPD) Show undefined attributes

catalystActivity	[CatalystActivity:10232441] AMP deaminase activity of AMPD tetramers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10232443
displayName	AMP + H2O => IMP + NH4+ (AMPD)
eventOf	[Pathway:R-CFA-74217] Purine salvage - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Canis familiaris
inferredFrom	[Reaction:R-HSA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Homo sapiens
input	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AMP + H2O => IMP + NH4+ (AMPD) AMP + H2O + H(+) => IMP + NH4(+)
output	[SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-CFA-74213] APRT catalyzes the conversion of adenine to AMP - Canis familiaris [Reaction:R-CFA-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-76590
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-74217] Purine salvage
(precedingEvent)	[Reaction:R-CFA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
(inferredTo)	[Reaction:R-HSA-76590] AMP + H2O => IMP + NH4+ (AMPD)

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