Reactome | Addition of the fourth nucleotide on the Nascent Transcript: Second Transition

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Addition of the fourth nucleotide on the Nascent Transcript: Second Transition Show undefined attributes

authored	[InstanceEdit:75951] Timmers, H. T. M., 2003-09-11 07:42:30
catalystActivity	[CatalystActivity:109910] DNA-directed RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75951] Timmers, H. T. M., 2003-09-11 07:42:30
dbId	75869
displayName	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
edited	[InstanceEdit:165073] Joshi-Tope, G, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-73776] RNA Polymerase II Promoter Escape - Homo sapiens
followingEvent	[Reaction:R-HSA-75856] Abortive Initiation Before Second Transition - Homo sapiens [Reaction:R-HSA-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Homo sapiens
input	[SimpleEntity:R-ALL-9757634] NTP [nucleoplasm] [Complex:R-HSA-75878] pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110387] Three transitions in the RNA polymerase II transcription complex during initiation. [LiteratureReference:111262] Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape.
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
orthologousEvent	[BlackBoxEvent:R-HSA-167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - Homo sapiens [BlackBoxEvent:R-SCE-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Dictyostelium discoideum [BlackBoxEvent:R-CEL-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Caenorhabditis elegans [BlackBoxEvent:R-DME-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Drosophila melanogaster [BlackBoxEvent:R-XTR-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Xenopus tropicalis [BlackBoxEvent:R-DRE-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Danio rerio [BlackBoxEvent:R-BTA-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Bos taurus [BlackBoxEvent:R-CFA-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Canis familiaris [BlackBoxEvent:R-RNO-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Rattus norvegicus [BlackBoxEvent:R-MMU-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-65888] GTF2B [nucleoplasm] [Complex:R-HSA-75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9613494] Unwinding of DNA for the Nascent Transcript: Second Transition - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-75869
summation	[Summation:111274] Formation of the third phosphodiester bond creates a 4-nt p...
updateTrackers	[UpdateTracker:9779103] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v66:[removeCatalystActivity] [UpdateTracker:9789870] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v37:[modifyText] [UpdateTracker:9775477] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v79:[add_removeInput] [UpdateTracker:9784082] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v54:[modifyText] [UpdateTracker:9784654] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v53:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779103] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v66:[removeCatalystActivity] [UpdateTracker:9789870] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v37:[modifyText] [UpdateTracker:9775477] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v79:[add_removeInput] [UpdateTracker:9784082] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v54:[modifyText] [UpdateTracker:9784654] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v53:[modifyText]
(hasEvent)	[Pathway:R-HSA-73776] RNA Polymerase II Promoter Escape
(precedingEvent)	[Reaction:R-HSA-75856] Abortive Initiation Before Second Transition [Reaction:R-HSA-75873] Addition of Nucleotides 5 through 9 on the growing Transcript

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