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Reaction
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Entries
Addition of Nucleotides 5 through 9 on the growing Transcript
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authored
[InstanceEdit:75951] Timmers, H. T. M., 2003-09-11 07:42:30
catalystActivity
[CatalystActivity:109910] DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:75951] Timmers, H. T. M., 2003-09-11 07:42:30
dbId
75873
displayName
Addition of Nucleotides 5 through 9 on the growing Transcript
edited
[InstanceEdit:165073] Joshi-Tope, G, 0000-00-00 00:00:00
eventOf
[Pathway:R-HSA-73776] RNA Polymerase II Promoter Escape - Homo sapiens
followingEvent
[Reaction:R-HSA-75891] Abortive Initiation After Second Transition - Homo sapiens
[Reaction:R-HSA-76576] Addition of nucleotides 10 and 11 on the growing transcript: Third Transition - Homo sapiens
input
5 ×
[SimpleEntity:R-ALL-9757634] NTP [nucleoplasm]
[Complex:R-HSA-75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:110387] Three transitions in the RNA polymerase II transcription complex during initiation.
[LiteratureReference:111275] Strong natural pausing by RNA polymerase II within 10 bases of transcription start may result in repeated slippage and reextension of the nascent RNA.
[LiteratureReference:110389] Recycling of the general transcription factors during RNA polymerase II transcription.
[LiteratureReference:111276] A role for TFIIH in controlling the activity of early RNA polymerase II elongation complexes.
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
Addition of Nucleotides 5 through 9 on the growing Transcript
orthologousEvent
[Reaction:R-HSA-167136] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript - Homo sapiens
[Reaction:R-SCE-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Saccharomyces cerevisiae
[Reaction:R-SPO-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Schizosaccharomyces pombe
[Reaction:R-DDI-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Dictyostelium discoideum
[Reaction:R-CEL-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Caenorhabditis elegans
[Reaction:R-DME-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Drosophila melanogaster
[Reaction:R-GGA-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Gallus gallus
[Reaction:R-SSC-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Sus scrofa
[Reaction:R-BTA-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Bos taurus
[Reaction:R-CFA-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Canis familiaris
[Reaction:R-RNO-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Rattus norvegicus
[Reaction:R-MMU-75873] Addition of Nucleotides 5 through 9 on the growing Transcript - Mus musculus
output
[Complex:R-HSA-75882] pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm]
5 ×
[SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
[Complex:R-HSA-109629] TFIIA [nucleoplasm]
[Complex:R-HSA-109626] TFIID [nucleoplasm]
[Complex:R-HSA-109633] TFIIE [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - Homo sapiens
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-75873
summation
[Summation:111277] Formation of the second phosphodiester bond creates a 3-nt p...
Referrals
(hasEvent)
[Pathway:R-HSA-73776] RNA Polymerase II Promoter Escape
(precedingEvent)
[Reaction:R-HSA-75891] Abortive Initiation After Second Transition
[Reaction:R-HSA-76576] Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
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