Reactome | Proteasome mediated degradation of Cyclin D1

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Proteasome mediated degradation of Cyclin D1 Show undefined attributes

catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003-06-05
dbId	75825
displayName	Proteasome mediated degradation of Cyclin D1
edited	[InstanceEdit:177986] Matthews, L, 2006-04-14 06:51:12
eventOf	[Pathway:R-HSA-75815] Ubiquitin-dependent degradation of Cyclin D - Homo sapiens
input	[Complex:R-HSA-177997] multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:177998] Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Proteasome mediated degradation of Cyclin D1
orthologousEvent	[BlackBoxEvent:R-DDI-75825] Proteasome mediated degradation of Cyclin D1 - Dictyostelium discoideum [BlackBoxEvent:R-CEL-75825] Proteasome mediated degradation of Cyclin D1 - Caenorhabditis elegans [BlackBoxEvent:R-DME-75825] Proteasome mediated degradation of Cyclin D1 - Drosophila melanogaster [BlackBoxEvent:R-GGA-75825] Proteasome mediated degradation of Cyclin D1 - Gallus gallus [BlackBoxEvent:R-XTR-75825] Proteasome mediated degradation of Cyclin D1 - Xenopus tropicalis [BlackBoxEvent:R-DRE-75825] Proteasome mediated degradation of Cyclin D1 - Danio rerio [BlackBoxEvent:R-SSC-75825] Proteasome mediated degradation of Cyclin D1 - Sus scrofa [BlackBoxEvent:R-BTA-75825] Proteasome mediated degradation of Cyclin D1 - Bos taurus [BlackBoxEvent:R-CFA-75825] Proteasome mediated degradation of Cyclin D1 - Canis familiaris [BlackBoxEvent:R-RNO-75825] Proteasome mediated degradation of Cyclin D1 - Rattus norvegicus [BlackBoxEvent:R-MMU-75825] Proteasome mediated degradation of Cyclin D1 - Mus musculus
output	3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-75824] Ubiquitination of Cyclin D1 - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-75825
summation	[Summation:177994] Phosphorylated Cyclin D1 is degraded during S phase by the 2...

Referrals

(hasEvent)	[Pathway:R-HSA-75815] Ubiquitin-dependent degradation of Cyclin D
(precedingEvent)	[NegativePrecedingEvent:9764010] Futile Cycle: Proteasome mediated degradation of Cyclin D1