Proteasome mediated degradation of Cyclin D1

Stable Identifier
R-HSA-75825
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Proteasome mediated degradation of Cyclin D1
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Phosphorylated Cyclin D1 is degraded during S phase by the 26S proteasome allowing for efficient DNA synthesis.
Literature References
PubMed ID Title Journal Year
15735756 Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis

Guo, Y, Yang, K, Harwalkar, J, Nye, JM, Mason, DR, Garrett, MD, Hitomi, M, Stacey, DW

Oncogene 2005
Participants
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Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome mediated degradation of Cyclin D1 (Bos taurus)
Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)
Proteasome mediated degradation of Cyclin D1 (Canis familiaris)
Proteasome mediated degradation of Cyclin D1 (Danio rerio)
Proteasome mediated degradation of Cyclin D1 (Dictyostelium discoideum)
Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)
Proteasome mediated degradation of Cyclin D1 (Gallus gallus)
Proteasome mediated degradation of Cyclin D1 (Mus musculus)
Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)
Proteasome mediated degradation of Cyclin D1 (Sus scrofa)
Proteasome mediated degradation of Cyclin D1 (Xenopus tropicalis)
Created
Walworth, N  (2003-06-05)
O'Donnell, M  (2003-06-05)
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