Reactome | Formation of RAD50:MRE11 complex

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Formation of RAD50:MRE11 complex Show undefined attributes

authored	[InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:73965] Thompson, L, 2003-07-14 15:03:24
dbId	75172
displayName	Formation of RAD50:MRE11 complex
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-59544] MRE11A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-75160] RAD50 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5687770] Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair [LiteratureReference:981730] The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of RAD50:MRE11 complex
orthologousEvent	[Reaction:R-MMU-75172] Formation of RAD50:MRE11 complex - Mus musculus [Reaction:R-PFA-75172] Formation of RAD50:MRE11 complex - Plasmodium falciparum [Reaction:R-SCE-75172] Formation of RAD50:MRE11 complex - Saccharomyces cerevisiae [Reaction:R-SPO-75172] Formation of RAD50:MRE11 complex - Schizosaccharomyces pombe [Reaction:R-DDI-75172] Formation of RAD50:MRE11 complex - Dictyostelium discoideum [Reaction:R-CEL-75172] Formation of RAD50:MRE11 complex - Caenorhabditis elegans [Reaction:R-DME-75172] Formation of RAD50:MRE11 complex - Drosophila melanogaster [Reaction:R-GGA-75172] Formation of RAD50:MRE11 complex - Gallus gallus [Reaction:R-XTR-75172] Formation of RAD50:MRE11 complex - Xenopus tropicalis [Reaction:R-DRE-75172] Formation of RAD50:MRE11 complex - Danio rerio [Reaction:R-SSC-75172] Formation of RAD50:MRE11 complex - Sus scrofa [Reaction:R-BTA-75172] Formation of RAD50:MRE11 complex - Bos taurus [Reaction:R-CFA-75172] Formation of RAD50:MRE11 complex - Canis familiaris [Reaction:R-RNO-75172] Formation of RAD50:MRE11 complex - Rattus norvegicus
output	[Complex:R-HSA-75161] RAD50:MRE11A [nucleoplasm]
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75172
summation	[Summation:75173] MRE11 has both manganese dependent ssDNA 3'->5' exonuclease ...
updateTrackers	[UpdateTracker:9784552] Update Tracker - [Reaction:75172] Formation of RAD50:MRE11 complex - v53:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784552] Update Tracker - [Reaction:75172] Formation of RAD50:MRE11 complex - v53:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks
(precedingEvent)	[Reaction:R-HSA-75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction

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