Reactome | Formation of RAD50:MRE11 complex

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Formation of RAD50:MRE11 complex Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11054874
displayName	Formation of RAD50:MRE11 complex
eventOf	[Pathway:R-SPO-5693548] Sensing of DNA Double Strand Breaks - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-75172] Formation of RAD50:MRE11 complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-SPO-59544] MRE11A [nucleoplasm] [EntityWithAccessionedSequence:R-SPO-75160] RAD50 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of RAD50:MRE11 complex
output	[Complex:R-SPO-75161] RAD50:MRE11A [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-75172
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-5693548] Sensing of DNA Double Strand Breaks
(precedingEvent)	[Reaction:R-SPO-75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction
(inferredTo)	[Reaction:R-HSA-75172] Formation of RAD50:MRE11 complex

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