Reactome | Formation of RAD50:MRE11 complex

Formation of RAD50:MRE11 complex

Stable Identifier

R-HSA-75172

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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MRE11 has both manganese dependent ssDNA 3'->5' exonuclease and endonuclease activities. MRE11 associates with RAD50, resulting in increased 3'-5' exonuclease activity (Dolganov et al. 1996, Paull and Gellert 1998).

Literature References

PubMed ID	Title	Journal	Year
8756642	Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair Dolganov, GM, Maser, RS, Novikov, A, Tosto, L, Chong, S, Bressan, DA, Petrini, JH	Mol. Cell. Biol.	1996
9651580	The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks Paull, TT, Gellert, M	Mol Cell	1998