MRE11 has both manganese dependent ssDNA 3'->5' exonuclease and endonuclease activities. MRE11 associates with RAD50, resulting in increased 3'-5' exonuclease activity (Dolganov et al. 1996, Paull and Gellert 1998).
Dolganov, GM, Maser, RS, Novikov, A, Tosto, L, Chong, S, Bressan, DA, Petrini, JH
Paull, TT, Gellert, M
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