Reactome | Liganded G12/13-activating GPCR acts as a GEF for G12/13

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Liganded G12/13-activating GPCR acts as a GEF for G12/13 Show undefined attributes

catalystActivity	[CatalystActivity:10144005] guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144007
displayName	Liganded G12/13-activating GPCR acts as a GEF for G12/13
eventOf	[Pathway:R-RNO-416482] G alpha (12/13) signalling events - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-RNO-750994] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Liganded G12/13-activating GPCR acts as a GEF for G12/13
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-RNO-751015] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-751029
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-416482] G alpha (12/13) signalling events
(inferredTo)	[Reaction:R-HSA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13

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