Phosphorylation of SHC1

Stable Identifier
Reaction [transition]
Homo sapiens
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SHC1 is tyrosine phosphorylated at Tyr-427 by the insulin receptor, later falling away from the receptor. Phosphorylation of SHC1 allows the SH2 domain of GRB2 to bind it (Sasaoka et al. 2000).

Literature References
PubMed ID Title Journal Year
11075717 The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

Sasaoka, T, Kobayashi, M

Endocr. J. 2000
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Imamura, T, Sawa, T, Sasaoka, T, Usui, I, Takata, Y, Ishihara, H, Kobayashi, M, Morioka, H, Ishiki, M

J. Biol. Chem. 1996
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]

Orthologous Events
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