Phosphorylation of SHC1

Stable Identifier
R-HSA-74742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SHC1 is tyrosine phosphorylated at Tyr-427 by the insulin receptor, later falling away from the receptor. Phosphorylation of SHC1 allows the SH2 domain of GRB2 to bind it (Sasaoka et al. 2000).

Literature References
PubMed ID Title Journal Year
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Sasaoka, T, Ishihara, H, Sawa, T, Ishiki, M, Morioka, H, Imamura, T, Usui, I, Takata, Y, Kobayashi, M

J. Biol. Chem. 1996
11075717 The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

Sasaoka, T, Kobayashi, M

Endocr. J. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Created